Using CRISPR-Cas9 for Therapeutic Protein Production (Review Article)
نویسندگان
چکیده
منابع مشابه
Efficient Production of Biallelic RAG1 Knockout Mouse Embryonic Stem Cell Using CRISPR/Cas9
Background: Recombination Activating Genes (RAG) mutated embryonic stem cells are (ES) cells which are unable to perform V (D) J recombination. These cells can be used for generation of immunodeficient mouse. Creating biallelic mutations by CRISPR/Cas9 genome editing has emerged as a powerful technique to generate site-specific mutations in different sequences. Ob...
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اصلاح هدفمند ژنومی با استفاده از نوکلئازهای هدایت شونده توسط RNA روشی سریع، آسان و پربازده است که نه تنها امکان دستکاری و تغییر ژنها و مطالعات کارکردی را برای پژوهشگران فراهم نموده است، بلکه آگاهی آنها را در رابطه با اساس مولکولی بیماریها و ابداع روشهای درمانی نوین و هدفمند افزایش داده است. تاکنون فنون متفاوتی با عنوان قیچیهای مولکولی با قابلیت ویرایش هدفمند ژنوم شاملZFN ،TALEN وCRISPR/Ca...
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ژورنال
عنوان ژورنال: Asian Journal of Pharmacy, Nursing and Medical Sciences
سال: 2021
ISSN: 2321-3639
DOI: 10.24203/ajpnms.v9i1.6115